Pharmacogenetic Analysis of Genes Implicated in Rodent Models of Antidepressant Response: Association of TREK1 and Treatment Resistance in the STAR*D Study

@article{Perlis2008PharmacogeneticAO,
  title={Pharmacogenetic Analysis of Genes Implicated in Rodent Models of Antidepressant Response: Association of TREK1 and Treatment Resistance in the STAR*D Study},
  author={Roy H. Perlis and Priya G. Moorjani and Jesen A. Fagerness and Shaun M Purcell and Madhukar H. Trivedi and Maurizio Fava and A. John Rush and Jordan W. Smoller},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={2810-2819}
}
Recent rodent models of antidepressant response implicate a novel set of genes in mechanisms of antidepressant action. The authors examined variants in four such genes (KCNK2 (TREK1), SLC18A2 (VMAT2), S100A10, and HDAC5) for association with remission in a large effectiveness trial of antidepressant treatments. Subjects were drawn from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, a multicenter, prospective, effectiveness trial in major depressive disorder (MDD… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

The inventory of depressive symptomatology (IDS): clinician (IDS-C) and selfreport (IDS-SR) ratings of depressive symptoms

  • AJ Rush, T Carmody, P Reimitz
  • Int J Methods Psychiatr Res
  • 2000
Highly Influential
6 Excerpts

Similar Papers

Loading similar papers…