Pharmacoepigenomics of opiates and methadone maintenance treatment: current data and perspectives.

Abstract

Current treatments of opioid addiction include primarily maintenance medications such as methadone. Chronic exposure to opiate and/or long-lasting maintenance treatment induce modulations of gene expression in brain and peripheral tissues. There is increasing evidence that epigenetic modifications underlie these modulations. This review summarizes published… (More)
DOI: 10.2217/pgs-2017-0040

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