Pharmacodynamics of ticlopidine in man in relation to plasma and blood cell concentration

  title={Pharmacodynamics of ticlopidine in man in relation to plasma and blood cell concentration},
  author={Tullio Di Perri and Franco Laghi Pasini and Clara Frigerio and Patrizia Blardi and Fabio Centini and Gianpaolo Messa and Angelo Ghezzi and Luciana Volpi},
  journal={European Journal of Clinical Pharmacology},
In 6 normal volunteers given single oral doses of 250, 500 and 1000 mg ticlopidine (T), the peak plasma level of unchanged drug was reached after about 2 h. There was no correlation between the plasma T level and its inhibitory effect on platelet function, expressed as % inhibition of ADP-induced aggregation. By means of HPLC and GC/MS significant concentrations of T were demonstrated in washed red cells, platelets and neutrophils, with a marked difference in the time course of the appearance… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 11 extracted citations


Publications referenced by this paper.
Showing 1-10 of 22 references

A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients

  • WK Hass, D Easton, +4 authors B Kamm
  • N Engl J Med
  • 1989
1 Excerpt

Broad spectrum antiplatelet activity of ticlopidine and PCR 4099 involves the suppression of the effect of released ADR Thromb Res

  • R Feliste, B Delebassee, MF Simon
  • 1987

Similar Papers

Loading similar papers…