Pharmacodynamics of the initiation of antiarrhythmic therapy with lorcainide.

  title={Pharmacodynamics of the initiation of antiarrhythmic therapy with lorcainide.},
  author={R. Winkle and D. Keefe and I. Rodr{\'i}guez and R. Kates},
  journal={The American journal of cardiology},
  volume={53 4},
  • R. Winkle, D. Keefe, +1 author R. Kates
  • Published 1984
  • Medicine
  • The American journal of cardiology
  • Lorcainide is an antiarrhythmic drug with unusual pharmacokinetics and an active metabolite, norlorcainide, which complicate oral drug loading. In order to characterize the accumulation of lorcainide and norlorcainide and to define the onset of antiarrhythmic action during lorcainide loading, 9 patients with frequent ventricular ectopic beats were studied. During lorcainide loading with 100 mg orally twice daily, frequent ambulatory electrocardiographic recordings were monitored and blood… CONTINUE READING
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