Pharmacodynamics of subcutaneously administered diacetylmorphine, 6-acetylmorphine and morphine in mice.

@article{Umans1981PharmacodynamicsOS,
  title={Pharmacodynamics of subcutaneously administered diacetylmorphine, 6-acetylmorphine and morphine in mice.},
  author={Jason G Umans and Charles E. Inturrisi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1981},
  volume={218 2},
  pages={
          409-15
        }
}
Diacetylmorphine (DAM) and 6-acetylmorphine (AM) exhibit virtually identical dose-response and time-action profiles in studies in antinociceptive, excitatory, antidiarrheal and antidiuretic activity after subcutaneous administration to mice. In antinociceptive (Haffner tail clip, phenylquinone writhing and hot plate) and excitatory (Straub tail) tests, both drugs are 3 to 10 times more potent than morphine (M) and reach their peak effect more rapidly than M. Analysis of these data by graded and… CONTINUE READING

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