Pharmacodynamics of simulated total versus free-drug serum concentrations of a low versus a high protein bound third-generation oral cephalosporin (Cefpodoxime versus cefditoren) against Streptococcus pneumoniae.

@article{Echeverra2007PharmacodynamicsOS,
  title={Pharmacodynamics of simulated total versus free-drug serum concentrations of a low versus a high protein bound third-generation oral cephalosporin (Cefpodoxime versus cefditoren) against Streptococcus pneumoniae.},
  author={Olatz Echeverr{\'i}a and Luis Alou and David Sevillano and Natalia Gonz{\'a}lez and Mar{\'i}a Luisa G{\'o}mez-Lus and Lorenzo Aguilar and Jos{\'e} Joaqu{\'i}n Prieto},
  journal={Journal of chemotherapy},
  year={2007},
  volume={19 3},
  pages={288-94}
}
Pharmacodynamic parameters and bactericidal activity against Streptococcus pneumoniae were investigated by simulating total and free serum concentrations of cefpodoxime versus cefditoren. Total drug T>MIC against the penicillin-intermediate (PISP) and resistant (PRSP) strains were 70.6% and 42.9% for cefpodoxime, and 89.6% and 62.5% for cefditoren, respectively. Comparing activity of free versus total cefpodoxime, there were reductions of 8.5% and 19.1% in T>MIC, related to bactericidal… CONTINUE READING

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