Pharmacodynamics of plasma nitrate/nitrite as an indication of nitric oxide formation in conscious dogs.

@article{Zeballos1995PharmacodynamicsOP,
  title={Pharmacodynamics of plasma nitrate/nitrite as an indication of nitric oxide formation in conscious dogs.},
  author={Guillermo A. Zeballos and Robert Bernstein and Carl I. Thompson and Paul R. Forfia and Nahid Seyedi and Weiqun Shen and P M Kaminiski and Michael S. Wolin and Thomas H. Hintze},
  journal={Circulation},
  year={1995},
  volume={91 12},
  pages={2982-8}
}
BACKGROUND The present investigation was undertaken to better understand the production of nitric oxide (NO) in vivo as measured by alterations in plasma nitrite or nitrate in blood samples from studies in experimental animals or clinical studies in humans. METHODS AND RESULTS Plasma samples were taken from the aorta, the coronary sinus, a peripheral vein in the leg (skeletal muscle), or the right ventricle (mixed venous) in chronically instrumented conscious dogs. Plasma nitrite was… CONTINUE READING