Pharmacodynamics of diazepam co-administered with methadone or buprenorphine under high dose conditions in opioid dependent patients.

@article{Lintzeris2007PharmacodynamicsOD,
  title={Pharmacodynamics of diazepam co-administered with methadone or buprenorphine under high dose conditions in opioid dependent patients.},
  author={Nicholas Lintzeris and Timothy B. Mitchell and Alyson J. Bond and Liam Nestor and John Strang},
  journal={Drug and alcohol dependence},
  year={2007},
  volume={91 2-3},
  pages={
          187-94
        }
}
BACKGROUND Benzodiazepine abuse is common among methadone- and buprenorphine-maintained patients; however interactions between these drugs under high dose conditions have not been adequately examined under controlled conditions. OBJECTIVE To investigate the effects of co-administering diazepam with methadone or buprenorphine under high dose conditions. DESIGN Double-blind, randomly ordered, 2 x 2 cross-over design in which the effects of diazepam dose (0mg versus 40 mg) and opioid dose (100… CONTINUE READING

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