Pharmacodynamics of dalbavancin studied in an in vitro pharmacokinetic system.

@article{Bowker2006PharmacodynamicsOD,
  title={Pharmacodynamics of dalbavancin studied in an in vitro pharmacokinetic system.},
  author={Karen E. Bowker and Alan R. Noel and Alasdair P Macgowan},
  journal={The Journal of antimicrobial chemotherapy},
  year={2006},
  volume={58 4},
  pages={
          802-5
        }
}
OBJECTIVES The antibacterial effect of dalbavancin was studied against Staphylococcus aureus using stepwise declining concentrations designed to model a range of free drug concentrations observed in human serum. METHODS Initial concentrations ranged from 0.6 to 21 mg/L and experiments were conducted over 240 h. Three vancomycin-susceptible and one vancomycin-intermediate strain of S. aureus were used. RESULTS AND CONCLUSIONS Dalbavancin showed non-concentration-dependent killing against the… CONTINUE READING
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