Pharmacodynamics of ceftazidime and meropenem in cerebrospinal fluid: results of population pharmacokinetic modelling and Monte Carlo simulation.

@article{Lodise2007PharmacodynamicsOC,
  title={Pharmacodynamics of ceftazidime and meropenem in cerebrospinal fluid: results of population pharmacokinetic modelling and Monte Carlo simulation.},
  author={Thomas P. Lodise and Roland Nau and Martina Kinzig and George L. Drusano and Ronald N. Jones and Fritz Soergel},
  journal={The Journal of antimicrobial chemotherapy},
  year={2007},
  volume={60 5},
  pages={1038-44}
}
BACKGROUND Ceftazidime and meropenem are frequently used in the empirical treatment of hospital-acquired cerebrospinal fluid (CSF) infections. Although their dispositions in CSF have been described, the ability of these agents to achieve critical pharmacodynamic targets against the array of nosocomial CSF Gram-negative bacteria encountered in practice has not been reported. METHODS Serum and CSF pharmacokinetic data were obtained from hospital patients with external ventricular drains and who… CONTINUE READING