Pharmacodynamics of Oestrogens and Progestogens

@article{deLignires2000PharmacodynamicsOO,
  title={Pharmacodynamics of Oestrogens and Progestogens},
  author={Bruno de Ligni{\`e}res and S D Silberstein},
  journal={Cephalalgia},
  year={2000},
  volume={20},
  pages={200 - 207}
}
The ovaries cyclically secrete estradiol and progesterone. Cyclic ovarian estradiol secretion is associated with a bone-saving and vascular protection effect. Endogenous progesterone does not modify the vasodilator effect of oestrogens. At physiological concentrations, the natural sex steroids have low antigonadotropic effects. More potent synthetic derivatives with more antigonadotropic effects were synthesized in the 1950s. After the menopause, there is no longer any need to use hormonal… 

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