Pharmacodynamics for antifungal drug development: an approach for acceleration, risk minimization and demonstration of causality.


The treatment of invasive fungal diseases constitutes a significant unmet medical need. There are relatively few antifungal agents in clinical development and a paucity of novel targets. Morbidity and mortality remain high and clinical outcomes are compromised by submaximal efficacy, emergence of drug resistance and drug-related toxicity. Thus, new… (More)


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