Pharmacodynamics and pharmacokinetics of inhaled iloprost, aerosolized by three different devices, in severe pulmonary hypertension.

@article{Olschewski2003PharmacodynamicsAP,
  title={Pharmacodynamics and pharmacokinetics of inhaled iloprost, aerosolized by three different devices, in severe pulmonary hypertension.},
  author={Horst Olschewski and Beate Rohde and J{\"u}rgen Behr and Ralph Ewert and Tobias Gessler and Hossein Ardeschir Ghofrani and Thomas Schmehl},
  journal={Chest},
  year={2003},
  volume={124 4},
  pages={1294-304}
}
BACKGROUND Inhalation of iloprost, a stable prostacyclin analog, is an effective therapy for pulmonary hypertension with few side effects. This approach may, however, be handicapped by limitations of currently available nebulization devices. We assessed whether the physical characterization of a device is sufficient to predict drug deposition and… CONTINUE READING