Pharmacodynamic profile of tramadol in humans: influence of naltrexone pretreatment

  title={Pharmacodynamic profile of tramadol in humans: influence of naltrexone pretreatment},
  author={William W Stoops and Michelle R. Lofwall and Paul A. Nuzzo and Lori B. Craig and Anthony J. Siegel and Sharon L. Walsh},
Tramadol is a prescription analgesic that activates mu opioid and monoamine receptor systems. Tramadol is thought to have limited abuse potential compared to mu opioid agonists, but laboratory data indicate that it shares some of their pharmacodynamic effects. This study evaluated the effect of mu opioid receptor blockade with naltrexone on the pharmacodynamic action of tramadol in humans. This inpatient, double-blind, randomized, within-subject study examined the effects of oral placebo… CONTINUE READING


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