Pharmacodynamic profile of prostacyclin.

  title={Pharmacodynamic profile of prostacyclin.},
  author={John R. Vane and R. M. Botting},
  journal={The American journal of cardiology},
  volume={75 3},
Since the 1930s and the discovery by von Euler of a vasoactive, lipid-soluble substance that he erroneously assumed was generated by the prostate gland and therefore should be called "prostaglandin," the family of prostaglandins has grown to some 90 substances. These lipid mediators are derived from arachidonic acid in the "arachidonic acid cascade." In 1976, while looking for the enzyme that generates the unstable prostanoid thromboxane A2 from arachidonic acid, Moncada and Vane discovered… CONTINUE READING