Pharmacodynamic profile of Zaleplon, a new non‐benzodiazepine hypnotic agent

@article{Patat2001PharmacodynamicPO,
  title={Pharmacodynamic profile of Zaleplon, a new non‐benzodiazepine hypnotic agent},
  author={Alain A. Patat and Isabelle Paty and Ian Hindmarch},
  journal={Human Psychopharmacology: Clinical and Experimental},
  year={2001},
  volume={16}
}
The challenge in developing hypnotic agents for the treatment of insomnia is to balance the sedative effect needed at bedtime with the residual sedation on awakening. Zaleplon is a novel pyrazolopyrimidine hypnotic agent that acts as a selective agonist to the brain omega1 receptor situated on the alpha1 subunit of the GABAA receptor complex. Zaleplon was proven to be an effective hypnotic drug as it consistently and significantly reduced latency to persistent sleep in insomniac patients for… 

Comparative Pharmacokinetics and Pharmacodynamics of Short-Acting Hypnosedatives

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  • 2004
While zaleplon may be best indicated for the delayed onset of sleep, zolpidem and zopiclone may be better indicated for maintaining a complete night’s sleep.

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In the Zzz Zone: The Effects of Z-Drugs on Human Performance and Driving

  • N. Gunja
  • Psychology
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The risk–benefit analysis of Z-drugs in the treatment of insomnia, particularly in the elderly, may not favor treatment due to the increased risks of falls and motor vehicle collisions.

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