Pharmacodynamic monitoring of molecular-targeted agents in the peripheral blood of leukemia patients using flow cytometry.

@article{Hedley2008PharmacodynamicMO,
  title={Pharmacodynamic monitoring of molecular-targeted agents in the peripheral blood of leukemia patients using flow cytometry.},
  author={David Hedley and Sue Chow and Charles Goolsby and T. Vincent Shankey},
  journal={Toxicologic pathology},
  year={2008},
  volume={36 1},
  pages={133-9}
}
The introduction of specific, molecular-targeted drugs is radically changing cancer treatment. Pharmacodynamics, which measures drug effects on the host, is key during early-phase clinical trials of novel agents to determine the relations between drug dose and target inhibition as well as measure the downstream effects of target inhibition on the cancer. In… CONTINUE READING