Pharmacodynamic modeling of aminoglycosides against Pseudomonas aeruginosa and Acinetobacter baumannii: identifying dosing regimens to suppress resistance development.

@article{Tam2008PharmacodynamicMO,
  title={Pharmacodynamic modeling of aminoglycosides against Pseudomonas aeruginosa and Acinetobacter baumannii: identifying dosing regimens to suppress resistance development.},
  author={Vincent H. Tam and Kimberly R Ledesma and Giao Vo and Samer Kabbara and T Lim and Michael Nikolaou},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 11},
  pages={3987-93}
}
To facilitate optimal dosing regimen design, we previously developed a mathematical model using time-kill study data to predict the responses of Pseudomonas aeruginosa to various pharmacokinetic profiles of meropenem and levofloxacin. In this study, we extended the model to predict the activities of gentamicin and amikacin exposures against P. aeruginosa and Acinetobacter baumannii, respectively. The input data were from a time-kill study with 10(7) CFU/ml of bacteria at baseline. P. aeruginosa… CONTINUE READING