Pharmacodynamic interpretation of adrenocorticotropin stimulation tests.

  title={Pharmacodynamic interpretation of adrenocorticotropin stimulation tests.},
  author={Mark A. Milad and William J. Jusko},
  journal={The Annals of pharmacotherapy},
  volume={27 10},
OBJECTIVE To report a pharmacodynamic model that describes increases in cortisol concentrations during administration of an adrenocorticotropin (ACTH) infusion, taking into account both steroid secretion and elimination. DATA SOURCES Previously published data. DATA SYNTHESIS Using a population estimate of the elimination rate constant for cortisol and… CONTINUE READING