Pharmacodynamic interactions of antibiotics alone and in combination.


Clinical trials show that the area under the inhibitory curve (AUIC) is predictive of antibacterial killing rates in patients with nosocomial pneumonia and is useful for predicting clinical or microbiological outcomes and making dosage adjustments with beta-lactams, quinolones, aminoglycosides, and vancomycin. The AUIC values of two antibiotics are additive… (More)


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@article{Schentag1998PharmacodynamicIO, title={Pharmacodynamic interactions of antibiotics alone and in combination.}, author={Jerome J. Schentag and L C Strenkoski-Nix and Don Nix and Alistair R R Forrest}, journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America}, year={1998}, volume={27 1}, pages={40-6} }