Pharmacodynamic evaluation of tigecycline against Acinetobacter baumannii in a murine pneumonia model.

@article{Koomanachai2009PharmacodynamicEO,
  title={Pharmacodynamic evaluation of tigecycline against Acinetobacter baumannii in a murine pneumonia model.},
  author={Pornpan Koomanachai and Aryun Kim and David P Nicolau},
  journal={The Journal of antimicrobial chemotherapy},
  year={2009},
  volume={63 5},
  pages={982-7}
}
OBJECTIVES Tigecycline is an extended-spectrum antibiotic with activity against Acinetobacter spp. (ACB), an increasingly common cause of nosocomial pneumonia. Although this compound is under investigation for this indication, supportive pharmacodynamic data are not yet available at this infection site. The objective of this study was to characterize the exposure-response relationship of tigecycline with ACB in an established murine pneumonia model. METHODS The pharmacokinetic profile of… CONTINUE READING
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Pharmacodynamic profile of tigecycline against phenotypically diverse Escherichia coli and Klebsiella pneumoniae in a murine thigh model

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