Pharmacodynamic evaluation of the first dose of mycophenolate mofetil before kidney transplantation.

@article{Kamar2009PharmacodynamicEO,
  title={Pharmacodynamic evaluation of the first dose of mycophenolate mofetil before kidney transplantation.},
  author={Nassim Kamar and Hans-H. Neumayer and Jochen Nolting and T. Jeffery Holland Boehler and Pia Hambach and Lutz Liefeldt and Lionel Rostaing and Klemens Budde},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  year={2009},
  volume={4 5},
  pages={
          936-42
        }
}
BACKGROUND AND OBJECTIVES The effect of mycophenolate mofetil (MMF) on T cell function has not been evaluated in patients undergoing kidney transplantation. The aim of this study was to assess the effect of 1g of MMF on T cell function, that is, intralymphocyte cytokine expression, T cell activation (CD25 and CD71), and T cell proliferation, as well as inosine monophosphate dehydrogenase (IMPDH) activity, to better understand the relationship between pharmacokinetic and pharmacodynamic markers… CONTINUE READING

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