Pharmacodynamic evaluation of the activity of antibiotics against hemin- and menadione-dependent small-colony variants of Staphylococcus aureus in models of extracellular (broth) and intracellular (THP-1 monocytes) infections.

@article{Garcia2012PharmacodynamicEO,
  title={Pharmacodynamic evaluation of the activity of antibiotics against hemin- and menadione-dependent small-colony variants of Staphylococcus aureus in models of extracellular (broth) and intracellular (THP-1 monocytes) infections.},
  author={Laetitia G. Garcia and Sandrine Lemaire and Barbara C Kahl and Karsten Becker and Richard A. Proctor and Olivier Denis and Paul M Tulkens and Françoise Van Bambeke},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 7},
  pages={3700-11}
}
Staphylococcus aureus small-colony variants (SCVs) persist intracellularly, which may contribute to persistence/recurrence of infections and antibiotic failure. We have studied the intracellular fate of menD and hemB mutants (corresponding to menadione- and hemin-dependent SCVs, respectively) of the COL methicillin-resistant S. aureus (MRSA) strain and the antibiotic pharmacodynamic profile against extracellular (broth) and intracellular (human THP-1 monocytes) bacteria. Compared to the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 64 references

Identification of a highly transmissible animal-independent Staphylococcus aureus ST398 clone with distinct genomic and cell adhesion properties

  • AC Uhlemann
  • mBio 3(2):e00027–12
  • 2012

Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary

  • C Liu
  • Clin. Infect
  • 2011

Contrasting effects of acidic pH on the extracellular and intracellular activities of the anti-grampositive fluoroquinolones moxifloxacin and delafloxacin against Staphylococcus aureus

  • S Lemaire, PM Tulkens, F. Van Bambeke
  • Antimicrob. Agents Chemother
  • 2011

Similar Papers

Loading similar papers…