Pharmacodynamic evaluation of 4 angiotensin-converting enzyme inhibitors in healthy adult horses.

@article{Afonso2013PharmacodynamicEO,
  title={Pharmacodynamic evaluation of 4 angiotensin-converting enzyme inhibitors in healthy adult horses.},
  author={Teresa Afonso and Steeve Gigu{\`e}re and George N. Rapoport and Londa J. Berghaus and M. H. Barton and Amanda E Coleman},
  journal={Journal of veterinary internal medicine},
  year={2013},
  volume={27 5},
  pages={
          1185-92
        }
}
BACKGROUND Angiotensin-converting enzyme (ACE) inhibitors are used in horses with cardiovascular disorders despite the paucity of available data regarding their efficacy. HYPOTHESIS The degree of serum ACE inhibition varies considerably between drugs. ANIMALS Eight healthy adult horses. METHODS Randomized prospective study. Horses were fasted overnight prior to receiving one of 4 ACE inhibitors intragastrically, administered at one of 2 dosages, using a randomized Latin square design… CONTINUE READING
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