Pharmacodynamic effects of subinhibitory concentrations of rufloxacin on bacterial virulence factors.

@article{Braga1999PharmacodynamicEO,
  title={Pharmacodynamic effects of subinhibitory concentrations of rufloxacin on bacterial virulence factors.},
  author={Pier Carlo Braga and Miquel Sala and M. Dal Sasso},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 5},
  pages={
          1013-9
        }
}
It has been reported that subinhibitory concentrations (sub-MICs) of some fluoroquinolones are still capable of affecting the topological characteristics of DNA (inhibition DNA-gyrase) and that this leads to a reduction in some of the factors responsible for bacterial virulence (by means of the disruption of protein synthesis and alterations in phenotype expression), even though the microorganisms themselves are not killed. The present study investigated the ability of sub-MICs of rufloxacin… CONTINUE READING

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