Pharmacodynamic effects of serotonin (5-HT) receptor ligands in pigs: stimulation of 5-HT2 receptors induces malignant hyperthermia

@article{Lscher1990PharmacodynamicEO,
  title={Pharmacodynamic effects of serotonin (5-HT) receptor ligands in pigs: stimulation of 5-HT2 receptors induces malignant hyperthermia},
  author={Wolfgang L{\"o}scher and Ulrike Witte and Gabriele Fredow and Mark A. Ganter and Klaus Bickhardt},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1990},
  volume={341},
  pages={483-493}
}
In pigs, the serotonin-2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), 0.8 mg/kg, induced “psychotic” behaviour (e. g., grimacing, backward locomotion, blank stare) and a muscular syndrome, which is known as malignant hyperthermia (MH) in pigs and humans. This syndrome is characterized by generalized skeletal muscle rigidity, leading to an increase in body temperature, marked acidosis, hyperkaliaemia, cyanosis and elevation of lactate, carbon dioxide and the… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Behavioural effects induced by stimulation of different serotonin ( 5 - HT ) receptor subtypes in swine : indication of marked species differences in 5 - HT receptor mediated events ( abstract )

  • W scher, U Graeber
  • Naunyn - Schmiedeberg ' s Arch Pharmacol
  • 1989

[ 125 I ] DO I and [ 3 H ] ketamine binding reveal 5 - HT 2 receptor agonist high affinity states in human , rat , and bovine brain

  • S Leonhardt, M Titeler
  • Naunyn - Schmiedeberg ' s Arch Pharmacol
  • 1989

5 - Hydroxytryptamineinduced tachycardia in the pig : possible involvement of a new type of 5 - hydroxytryptamine receptor

  • AH Born, DJ Duncker, PR Saxena, PD Verdouw
  • Br J Pharmacol
  • 1988

Effects of 5 - HT on porcine ear veins

  • E Schneider, W Felix, G Steigerwald
  • Naunyn - Schmiedeberg ' s Arch Pharmacol
  • 1988

Similar Papers

Loading similar papers…