Pharmacodynamic effects of seliciclib, an orally administered cell cycle modulator, in undifferentiated nasopharyngeal cancer.

@article{Hsieh2009PharmacodynamicEO,
  title={Pharmacodynamic effects of seliciclib, an orally administered cell cycle modulator, in undifferentiated nasopharyngeal cancer.},
  author={Wen-son Hsieh and Ross A. Soo and Bee-Keow Peh and Thomas Loh and Difeng Dong and Donny Soh and Lim-Soon Wong and Simon Green and Judy Chiao and Chun-Ying Cui and Yoke-Fong Lai and Soo-Chin Lee and Benjamin Mow and Richie Soong and Manuel Salto-Tellez and Boon-cher Goh},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 4},
  pages={1435-42}
}
PURPOSE Cell cycle dysregulation resulting in expression of antiapoptotic genes and uncontrolled proliferation is a feature of undifferentiated nasopharyngeal carcinoma. The pharmacodynamic effects of seliciclib, a cyclin-dependent kinase (CDK) inhibitor, were studied in patients with nasopharyngeal carcinoma. EXPERIMENTAL DESIGN Patients with treatment-naïve locally advanced nasopharyngeal carcinoma received seliciclib at 800 mg or 400 mg twice daily on days 1 to 3 and 8 to 12. Paired tumor… CONTINUE READING
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