Pharmacodynamic effects of prenalterol in healthy subjects.

@article{Johnsson1982PharmacodynamicEO,
  title={Pharmacodynamic effects of prenalterol in healthy subjects.},
  author={G. Johnsson},
  journal={Acta medica Scandinavica. Supplementum},
  year={1982},
  volume={659},
  pages={
          109-22
        }
}
  • G. Johnsson
  • Published 24 April 2009
  • Medicine
  • Acta medica Scandinavica. Supplementum
1. Prenalterol induces a dose-dependent effect on different variables reflecting myocardial contractility and heart rate. A clearcut effect can be demonstrated after an oral dose of 2.5 mg. The duration of the effect increases considerably when prenalterol is administered as a controlled release preparation partly due to an increased bioavailability. 2. Prenalterol induces a lipolytic effect manifested as a rise in free fatty acids and glycerol. Also a slight increase of plasma insulin is… 

References

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TLDR
A linear relationship was found between the plasma level of prenalterol and its effects on systolic blood pressure and heart rate and it was found that the plasma levels were related to the haemodynamic effects.
Haemodynamic effects and pharmacokinetics of a new selective beta1-adrenoceptor agonist, prenalterol, and its interaction with metoprolol in man
TLDR
Prenalterol was rapidly distributed with an average half life of 8 min, which indicates that distribution equilibrium will be achieved within 30 min after intravenous administration, and the overall elimination rate in the post-distributive phase corresponded to an averageHalf life of 2.0 h.
Interaction in Healthy Volunteers Between Prenalterol, A Selective β1‐Adrenoceptor Agonist, and Metoprolol or Propranolol
TLDR
It is suggested that prenalterol might be a useful drug to counteract undesired hemodynamic effects of β-adrenoceptor blockers.
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TLDR
It is suggested that the release of renin from the kidney may partly be mediated via an adrenergic beta1-receptor via a single dose of metoprolol or propranolol, both of which have been shown to block the action of furosemide in healthy subjects.
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TLDR
The two beta-receptor blockers inhibited isoprenaline-induced increase in chronotropy to about the same extent, while the effects on systolic and diastolic blood pressure were in accordance with a selective beta1-blocking effect of metoprolol and a non-selective beta-blocking action of propranolol.
Haemodynamic and tolerance studies in man of a new, orally active, selectiveβ1-adrenoceptor agonist H 80/62
TLDR
The selective β1-adrenoceptor agonist H 80/62 was administered intravenously and orally to healthy subjects and its effects on systolic time intervals, arterial blood pressure and heart rate were studied and the drug was well tolerated on repeated administration.
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TLDR
Though the two-dimensional echocardiographic estimates of M VA in rheumatic mitral valve disease are correlated with the anatomical area, their predictive value in the estimation of the true orifice size is poor in the individual patient, in view of the large discrepancy between the echOCardiographic and anatomical measurements found in this study.