Pharmacodynamic effects of chronic yohimbine treatment in healthy volunteers

  title={Pharmacodynamic effects of chronic yohimbine treatment in healthy volunteers},
  author={Jean Galitzky and Daniel Rivi{\`e}re and Michelle A Tran and J. L. Montastruc and Michel Berlan},
  journal={European Journal of Clinical Pharmacology},
The effects of 14 days of treatment with the alpha2-adrenoceptor antagonist yohimbine on cardiovascular parameters (blood pressure and heart rate), plasma catecholamines, insulin and non-esterified fatty acids (NEFA), and the number of alpha2-adrenoceptors on platelets have been evaluated. The treatment increased plasma noradrenaline but not adrenaline and did not change the other cardiovascular, metabolic or routine blood parameters. It caused a decrease in the velocity of adrenaline-induced… CONTINUE READING
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