Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials.

@article{Odonoghue2009PharmacodynamicEA,
  title={Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials.},
  author={Michelle O'donoghue and Eugene Braunwald and Elliott Marshall Antman and Sabina A. Murphy and Eric R. Bates and Yoseph Rozenman and Alan D Michelson and Raymond W. M. Hautvast and Peter N Ver Lee and Sandra L. Close and Lei Shen and Jessica L. Mega and Marc S. Sabatine and Stephen D. Wiviott},
  journal={Lancet},
  year={2009},
  volume={374 9694},
  pages={
          989-997
        }
}
BACKGROUND Proton-pump inhibitors (PPIs) are often prescribed in combination with thienopyridines. Conflicting data exist as to whether PPIs diminish the efficacy of clopidogrel. We assessed the association between PPI use, measures of platelet function, and clinical outcomes for patients treated with clopidogrel or prasugrel. METHODS In the PRINCIPLE-TIMI 44 trial, the primary outcome was inhibition of platelet aggregation at 6 h assessed by light-transmission aggregometry. In the TRITON… CONTINUE READING
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A national study of the eff ect of individual proton pump inhibitors on cardiovascular outcomes in patients treated with clopidogrel following coronary stenting : the Clopidogrel Medco Outcomes Study

  • SP Dunn, TE Macaulay, DM Brennan
  • Paper presented at : SCAI 32 nd Annual Scientifi…
  • 2009

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