Pharmacodynamic characterization of insulin on MDMA-induced thermogenesis.

  title={Pharmacodynamic characterization of insulin on MDMA-induced thermogenesis.},
  author={Matthew L Banks and Sarah K Buzard and Candice M Gehret and Alexa N Monroy and M Alexander Kenaston and Edward M. Mills and Jon E Sprague},
  journal={European journal of pharmacology},
  volume={615 1-3},
Sympathomimetic drugs (MDMA; ecstasy) induce a potentially catastrophic hyperthermia that involves free fatty acid (FFA) activation of mitochondrial uncoupling proteins (UCP). Insulin is an important regulator of plasma FFA levels, although its role in thermogenesis is unclear. The aims of the present study were 1) to characterize the pharmacodynamic effects of MDMA on plasma insulin and glucose, 2) to examine the effects of insulin on MDMA-induced thermogenesis and 3) to examine MDMA-induced… CONTINUE READING
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