Pharmacodynamic and pharmacokinetic properties of an angiotensin II receptor antagonist--characterization by use of Schild regression technique in man.

@article{BreithauptGrgler1997PharmacodynamicAP,
  title={Pharmacodynamic and pharmacokinetic properties of an angiotensin II receptor antagonist--characterization by use of Schild regression technique in man.},
  author={Kerstin Breithaupt-Gr{\"o}gler and Cornelius Malerczyk and Gustav Georg Belz and Raunhild Butzer and Veit Herrmann and Heino Stass and Georg Wensing},
  journal={International journal of clinical pharmacology and therapeutics},
  year={1997},
  volume={35 10},
  pages={434-41}
}
OBJECTIVE The pharmacodynamic properties of a new angiotensin II receptor antagonist (BAY 10-6734) in humans were to be quantitatively characterized from the rightward shifts of the agonist dose-response curves after administration of different doses of the antagonist. METHODS 24 healthy male volunteers received single oral doses of 20-300 mg BAY 10-6734. Before and up to 23 h post dosing (p.d.) plasma was obtained for HPLC measurement of parent compound and active metabolite BAY 10-6735… CONTINUE READING