Pharmacodynamic and pharmacokinetic evaluation of buprenorphine + samidorphan for the treatment of major depressive disorder
@article{Ragguett2018PharmacodynamicAP, title={Pharmacodynamic and pharmacokinetic evaluation of buprenorphine + samidorphan for the treatment of major depressive disorder}, author={Renee-Marie Ragguett and Carola Rong and Joshua D. Rosenblat and Roger Chun-Man Ho and Roger S. McIntyre}, journal={Expert Opinion on Drug Metabolism \& Toxicology}, year={2018}, volume={14}, pages={475 - 482} }
ABSTRACT Introduction: Treatment resistant depression (TRD) represents approximately 20% of all individuals receiving care for major depressive disorder. The opioidergic system is identified as a novel target which hitherto has not been sufficiently investigated in adults with TRD. The combination product buprenorphine + samidorphan is an opioid modulatory agent which has demonstrated replicated evidence of efficacy in TRD without abuse liability. Areas covered: Databases Pubmed, Google Scholar…
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