Pharmacodynamic and pharmacokinetic evaluation of buprenorphine + samidorphan for the treatment of major depressive disorder

@article{Ragguett2018PharmacodynamicAP,
  title={Pharmacodynamic and pharmacokinetic evaluation of buprenorphine + samidorphan for the treatment of major depressive disorder},
  author={Renee-Marie Ragguett and Carola Rong and Joshua D. Rosenblat and Roger Chun-Man Ho and Roger S. McIntyre},
  journal={Expert Opinion on Drug Metabolism \& Toxicology},
  year={2018},
  volume={14},
  pages={475 - 482}
}
ABSTRACT Introduction: Treatment resistant depression (TRD) represents approximately 20% of all individuals receiving care for major depressive disorder. The opioidergic system is identified as a novel target which hitherto has not been sufficiently investigated in adults with TRD. The combination product buprenorphine + samidorphan is an opioid modulatory agent which has demonstrated replicated evidence of efficacy in TRD without abuse liability. Areas covered: Databases Pubmed, Google Scholar… 
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