Pharmacodynamic and pharmacokinetic evaluation of buprenorphine + samidorphan for the treatment of major depressive disorder

@article{Ragguett2018PharmacodynamicAP,
  title={Pharmacodynamic and pharmacokinetic evaluation of buprenorphine + samidorphan for the treatment of major depressive disorder},
  author={Renee-Marie Ragguett and Carola Rong and Joshua D. Rosenblat and Roger Chun-Man Ho and Roger S. McIntyre},
  journal={Expert Opinion on Drug Metabolism \& Toxicology},
  year={2018},
  volume={14},
  pages={475 - 482}
}
ABSTRACT Introduction: Treatment resistant depression (TRD) represents approximately 20% of all individuals receiving care for major depressive disorder. The opioidergic system is identified as a novel target which hitherto has not been sufficiently investigated in adults with TRD. The combination product buprenorphine + samidorphan is an opioid modulatory agent which has demonstrated replicated evidence of efficacy in TRD without abuse liability. Areas covered: Databases Pubmed, Google Scholar… 
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11 Citations

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Modulation of the central opioid system as an antidepressant target in rodent models.
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TLDR
Relative bioavailability of OLZ in ALKS 3831, a bilayer tablets containing OLZ and SAM, a matching bilayer tablet containingOLZ only (OLZ), and Zyprexa (brand olanzapine [B‐OLZ]) was assessed in an open‐label study, demonstrating bioequivalence of OLz in AL KS 3831.
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The neurotrophic mechanisms of antidepressants are described and current and novel treatment modalities that can restore neural circuit function by directly engaging neuroplasticity are described.
A randomized, double‐blind, placebo‐controlled study of the kappa opioid receptor antagonist, CERC‐501, in a human laboratory model of smoking behavior
TLDR
CERC‐501 was well tolerated, but it did not significantly alter the latency to start smoking or the number of cigarettes smoked, and did not affect cigarette craving, mood, anxiety, nicotine withdrawal, or subjective effects of smoking.
Mice Lacking GABAA Receptor δ Subunit Have Altered Pharmaco-EEG Responses to Multiple Drugs
TLDR
Findings on pharmaco-EEG effects of 4-MMC suggest that δ-GABAARs are involved in the secondary indirect regulation of the brain rhythms after 4- MMC, and stimulants are not known to act on these receptors.
Novel therapeutic drug targets for bipolar disorder
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