Pharmacodynamic and pharmacokinetic effects of the intravenously administered CB1 receptor agonist Org 28611 in healthy male volunteers

@article{Zuurman2009PharmacodynamicAP,
  title={Pharmacodynamic and pharmacokinetic effects of the intravenously administered CB1 receptor agonist Org 28611 in healthy male volunteers},
  author={Lineke Zuurman and P Ccm Passier and M. L. de Kam and Huub Jan Kleijn and Adam F. Cohen and Joop M A van Gerven},
  journal={Journal of Psychopharmacology},
  year={2009},
  volume={23},
  pages={633 - 644}
}
Abstract CB1/CB2 agonists are reported to have sedative, amnestic, analgesic and anti-emetic properties, which would make them ideal drugs for outpatient treatments under conscious sedation. The main objective of this in human study was to assess the sedative properties of Org 28611, a potent water-soluble CB1 agonist. Single ascending doses were administered during a slow 25 min infusion and after a 1 min bolus administration to healthy male volunteers. In addition, the pharmacokinetics… 
Pharmacodynamic and pharmacokinetic effects of the intravenous CB1 receptor agonist Org 26828 in healthy male volunteers
TLDR
Although subjects reported subjective sedation after administration of Org 26828 at 3 and 6 μg/kg, the observed sedation was considerably less than after midazolam, and OrG 26828 is not suitable for providing sedation for outpatient surgical procedures.
Gerven healthy male volunteers Pharmacodynamic and pharmacokinetic effects of the intravenous CB 1 receptor agonist Org 26828 in
TLDR
Although subjects reported subjective sedation after administration of Org 26828 at 3 and 6 mg/kg, the observed sedation was considerably less than after midazolam, and OrG 26828 is not suitable for providing sedation for outpatient surgical procedures.
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