Pharmacodynamic and pharmacokinetic effects of TPA023, a GABAA α2,3 subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers

@article{Haas2007PharmacodynamicAP,
  title={Pharmacodynamic and pharmacokinetic effects of TPA023, a GABAA $\alpha$2,3 subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers},
  author={S. de Haas and S. D. de Visser and J. van der Post and M. De Smet and R. Schoemaker and B. Rijnbeek and A. Cohen and J. Vega and N. Agrawal and T. Goel and R. C. Simpson and L. K. Pearson and S. Li and M. Hesney and M. Murphy and J. V. van Gerven},
  journal={Journal of Psychopharmacology},
  year={2007},
  volume={21},
  pages={374 - 383}
}
TPA023, a GABAA α2,3 αsubtype-selective partial agonist, is expected to have comparable anxiolytic efficacy as benzodiazepines with reduced sedating effects. The compound Lacks efficacy at the α1 subtype, which is believed to mediate these effects. This study investigated the effects of 0.5 and 1.5 mg TPA023 and compared them with pLacebo and Lorazepam 2 mg (therapeutic anxioLytic dose). Twelve healthy maLe volunteers participated in this placebo-controlled, double-blind, double-dummy, four-way… Expand
The effects of TPA023, a GABAAα2,3 subtype-selective partial agonist, on essential tremor in comparison to alcohol
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