Pharmacodynamic and pharmacokinetic aspects on the transport of bronchodilator drugs through the tracheal epithelium of the guinea-pig.

@article{Jeppsson1989PharmacodynamicAP,
  title={Pharmacodynamic and pharmacokinetic aspects on the transport of bronchodilator drugs through the tracheal epithelium of the guinea-pig.},
  author={Annika Jeppsson and Christine M. Roos and Bertil Waldeck and Eva Widmark},
  journal={Pharmacology & toxicology},
  year={1989},
  volume={64 1},
  pages={58-63}
}
An isolated vagus nerve-trachea tube preparation from guinea-pig was used to study the effect kinetics of bronchodilating beta-adrenoceptor agonists. The test compounds were added either into the fluid-filled lumen or into the external medium and they all inhibited, dose-dependently and completely, the vagally induced contractions. The hydrophilic compounds… CONTINUE READING