Pharmacodynamic and antiretroviral activities of combination nanoformulated antiretrovirals in HIV-1-infected human peripheral blood lymphocyte-reconstituted mice.

@article{Roy2012PharmacodynamicAA,
  title={Pharmacodynamic and antiretroviral activities of combination nanoformulated antiretrovirals in HIV-1-infected human peripheral blood lymphocyte-reconstituted mice.},
  author={Upal Roy and JoEllyn McMillan and Yazen M Alnouti and Nagsen Gautum and Nathan Earl Smith and Shantanu S Balkundi and Prasanta Kumar Dash and Santhi Gorantla and Andrea L. Martinez-Skinner and Jane L. Meza and Georgette D Kanmogne and Susan S Swindells and Samuel M Cohen and R. Lee Mosley and Larisa Poluektova and Howard E. Gendelman},
  journal={The Journal of infectious diseases},
  year={2012},
  volume={206 10},
  pages={1577-88}
}
Lack of adherence, inaccessibility to viral reservoirs, long-term drug toxicities, and treatment failures are limitations of current antiretroviral therapy (ART). These limitations lead to increased viral loads, medicine resistance, immunocompromise, and comorbid conditions. To this end, we developed long-acting nanoformulated ART (nanoART) through modifications of existing atazanavir, ritonavir, and efavirenz suspensions in order to establish cell and tissue drug depots to achieve sustained… CONTINUE READING
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