Pharmacodynamic and Pharmacokinetic Features of Cabergoline

@article{Fariello2012PharmacodynamicAP,
  title={Pharmacodynamic and Pharmacokinetic Features of Cabergoline},
  author={Ruggero G. Fariello},
  journal={Drugs},
  year={2012},
  volume={55},
  pages={10-16}
}
SummaryThe appearance of late motor complications is the major drawback of long term levodopa therapy in patients with Parkinson’s disease. Although disease progression may be a factor in the aetiology of these complications, unfavourable properties of levodopa may promote their development. These include competition with amino acids for gastrointestinal absorption and passage through the blood-brain barrier; and a short duration of action with a rapid peak plasma concentration and rapid… 
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References

SHOWING 1-10 OF 61 REFERENCES
Pergolide. A review of its pharmacological properties and therapeutic potential in Parkinson's disease.
TLDR
Pergolide would appear to be at least as useful as other dopamine agonists such as bromocriptine or lisuride for the management of patients with Parkinson's disease when administered in combination with levodopa.
Cabergoline in the treatment of early parkinson's disease
TLDR
The results of this study indicate that cabergoline treatment for up to 1 year is only marginally less effective than levodopa in the proportion of patients who can be treated in monotherapy.
Cabergoline improves motor disability without modifying L-dopa plasma levels in fluctuating Parkinson's disease patients.
TLDR
It is confirmed that cabergoline is effective in the management of PD motor fluctuations without modifying L-dopa and 3-OMD pharmacokinetics.
A rationale for dopamine agonists as primary therapy for Parkinson's disease.
  • C. Olanow
  • Medicine
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
  • 1992
TLDR
Levodopa sparing strategies designed to minimize the cumulative levodopa dosage employed over the course of the disease seem a rational way to treat Parkinson patients in face of current information.
Motor complications associated with chronic levodopa therapy in Parkinson's disease.
TLDR
Patients with complex fluctuations are the least likely to improve with slow-release levodopa preparations, and drugs capable of providing a stable dopaminergic stimulation should be particularly useful for preventing the development of motor complications in patients not yet treated.
Bromocriptine lessens the incidence of mortality in L-Dopa-treated parkinsonian patients: Prado-study discontinued
TLDR
The results imply that combination therapy with bromocriptine should be preferred over L-Dopa monotherapy from the very beginning.
The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport.
TLDR
Interference with absorption oflevodopa by food and by competition between large neutral amino acids and levodopa for transport from plasma to the brain may be partly responsible for the fluctuating clinical response in patients with Parkinson's disease.
Increased life expectancy resulting from addition of l-deprenyl to Madopar® treatment in Parkinson's disease: A longterm study
TLDR
Results are interpreted as indicating l-deprenyl's ability to prevent or retard the degeneration of striatal dopaminergic neurons, the first anti-Parkinson drug having such a property.
Radioimmunoassay for the synthetic ergoline derivative cabergoline in biological fluids.
TLDR
The plasma concentrations at the steady state in a patient with Parkinson's disease who had received the drug at single oral daily doses of 3, 5 and 7 mg were determined using the assay, validated in terms of reproducibility, precision and accuracy.
Multicenter, placebo-controlled trial of cabergoline taken once daily in the treatment of Parkinson's disease
TLDR
It is concluded that cabergoline is an effective adjunct to levodopa for the treatment of PD.
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