Pharmacodynamic analysis of the activity of quinupristin-dalfopristin against vancomycin-resistant Enterococcus faecium with differing MBCs via time-kill-curve and postantibiotic effect methods.

@article{Aeschlimann1998PharmacodynamicAO,
  title={Pharmacodynamic analysis of the activity of quinupristin-dalfopristin against vancomycin-resistant Enterococcus faecium with differing MBCs via time-kill-curve and postantibiotic effect methods.},
  author={Jeffrey R. Aeschlimann and Michael Joseph Rybak},
  journal={Antimicrobial agents and chemotherapy},
  year={1998},
  volume={42 9},
  pages={2188-92}
}
Quinupristin-dalfopristin (Q-D) is a new water-soluble, semisynthetic antibiotic that is derived from natural streptogramins and that is combined in a 30:70 ratio. A number of studies have described the pharmacodynamic properties of this drug, but most have investigated only staphylococci or streptococci. We evaluated the relationship between Q-D, quinupristin (Q), and/or dalfopristin (D) susceptibility parameters and antibacterial activities against 22 clinical isolates of vancomycin-resistant… CONTINUE READING
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Inhibition of protein synthesis by streptogramins and related compounds

  • C. Cocito, M. Di Giambattista, E. Nyssen, P. Vannuuffel
  • J. Antimicrob. Chemother
  • 1997

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