Pharmacodynamic Interaction of Remifentanil and Dexmedetomidine on Depth of Sedation and Tolerance of Laryngoscopy.

@article{Weerink2019PharmacodynamicIO,
  title={Pharmacodynamic Interaction of Remifentanil and Dexmedetomidine on Depth of Sedation and Tolerance of Laryngoscopy.},
  author={Maud A. S. Weerink and Clemens R. M. Barends and Ernesto R R Muskiet and Koen M E M Reyntjens and Froukje H Knotnerus and Martine Oostra and Jan Van Bocxlaer and Michel M.R.F. Struys and Pieter J. Colin},
  journal={Anesthesiology},
  year={2019}
}
WHAT WE ALREADY KNOW ABOUT THIS TOPIC Patients sedated with standard clinical doses of dexmedetomidine can be readily arousedDexmedetomidine doses producing mild to deep sedation lack significant analgesic effectRemifentanil is an opioid analgesic with only modest sedative propertiesAddition of remifentanil to propofol sedation reduces the propofol concentration required to reach tolerance of shaking the patient while shouting their name and tolerance of laryngoscopy WHAT THIS ARTICLE TELLS US… 
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