Pharmacodynamic, pharmacokinetic and humoral effects of oral zabicipril, an angiotensin converting enzyme inhibitor in normotensive man.

@article{Macdonald1990PharmacodynamicPA,
  title={Pharmacodynamic, pharmacokinetic and humoral effects of oral zabicipril, an angiotensin converting enzyme inhibitor in normotensive man.},
  author={Natalie J Macdonald and Daniel M. Hughes and Kennedy R. Lees and John L. Reid},
  journal={British journal of clinical pharmacology},
  year={1990},
  volume={30 1},
  pages={
          107-13
        }
}
1. Zabicipril, S9650, a new angiotensin converting enzyme inhibitor, was administered to salt-replete, normotensive males in single doses of up to 10 mg. 2. The safety, tolerance and dose-response relationship with regard to inhibition of plasma ACE activity were characterised initially in an open, pilot, dose-finding study in 12 subjects and further explored in a double-blind, parallel group, placebo controlled study in another 30 subjects. 3. The drug was generally well tolerated and produced… 
6 Citations
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