Pharmaco- and toxicokinetics of selected exogenous and endogenous estrogens: A review of the data and identification of knowledge gaps

@article{Mattison2014PharmacoAT,
  title={Pharmaco- and toxicokinetics of selected exogenous and endogenous estrogens: A review of the data and identification of knowledge gaps},
  author={Donald R. Mattison and Nataliya A. Karyakina and Michael Goodman and Judy S LaKind},
  journal={Critical Reviews in Toxicology},
  year={2014},
  volume={44},
  pages={696 - 724}
}
Abstract Chemicals with estrogenic activity are derived from many different natural and synthetic processes and products, including endogenous production (e.g., estradiol, conjugated estrogens), drugs (e.g., ethinyl estradiol, conjugated estrogens), plants used as foods (phytoestrogens such as genistein, daidzein, S-equol), and man-made chemicals (xenoestrogens such as bisphenol A). Human exposure to low doses of endogenous estrogens, estrogenic drugs, phytoestrogens, and xenoestrogens has the… Expand
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References

SHOWING 1-10 OF 322 REFERENCES
Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens.
TLDR
The phytoestrogens showed a preference to bind to ER-beta, but only genistein showed a much lower activity in the E-Screen (growth induction in breast cancer cells) compared with the luciferase induction in MVLN and HGELN-cells. Expand
Metabolism and kinetics of bisphenol a in humans at low doses following oral administration.
TLDR
The efficient glucuronidation of bisphenol A and the rapid excretion of the formed glucuronide result in a low body burden of the estrogenic bispenol A in humans following oral absorption of low doses. Expand
Isoflavones: estrogenic activity, biological effect and bioavailability
TLDR
The evaluation of isoflavone metabolism and bioavailability is crucial to understanding their biological effects and Lipid-based formulations such as drug incorporation into oils, emulsions and self-microemulsifying formulations have been introduced to increase bioavailability. Expand
Pharmacology of conjugated equine estrogens: Efficacy, safety and mechanism of action
TLDR
Selective combinations of ring B unsaturated estrogens have the potential of being developed as novel therapeutic agents for the prevention of cardiovascular disease and Alzheimer's disease in both aging women and men. Expand
Pharmacokinetics and Pharmacodynamics of Conjugated Equine Estrogens: Chemistry and Metabolism
  • B. Bhavnani
  • Chemistry, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1998
TLDR
The pharmacokinetics of these estrogens indicate that the unconjugated estrogens are cleared from the circulation at a faster rate than their sulfate ester forms, and preparations lacking some of these important components may not offer the same degree of beneficial effects as Premarin. Expand
Physiologically-Based Pharmacokinetic Modeling of Genistein in Rats, Part I: Model Development
TLDR
A physiologically-based pharmacokinetic (PBPK) model to quantify the internal, target-tissue dosimetry of genistein in adult rats is developed and can serve as a template for other phytoestrogens and in the design of future experiments and research that can be used to fill data gaps and better estimate model parameters. Expand
Isoflavones made simple - genistein's agonist activity for the beta-type estrogen receptor mediates their health benefits.
  • M. Mccarty
  • Chemistry, Medicine
  • Medical hypotheses
  • 2006
TLDR
These considerations suggest that soy isoflavone regimens of sufficient potency may represent a safe and moderately effective alternative to HRT in postmenopausal women. Expand
Pharmacology of estrogens and progestogens: influence of different routes of administration
  • H. Kuhl
  • Medicine
  • Climacteric : the journal of the International Menopause Society
  • 2005
This review comprises the pharmacokinetics and pharmacodynamics of natural and synthetic estrogens and progestogens used in contraception and therapy, with special consideration of hormoneExpand
Bisphenol A interacts with the estrogen receptor α in a distinct manner from estradiol
TLDR
It is demonstrated that BPA is not merely a weak estrogen mimic but exhibits a distinct mechanism of action at the ERalpha, which is significantly less potent than E2 in activating ER-WT. Expand
Endocrine disrupting chemicals targeting estrogen receptor signaling: identification and mechanisms of action.
TLDR
Biological effects of EDCs need to be carefully interpreted because EDCs can act through complex tissue-selective modulation of ERs and other signaling pathways in vivo, according to current requirements by the U.S. Environmental Protection Agency. Expand
...
1
2
3
4
5
...