Pharmaco- and toxicokinetics of selected exogenous and endogenous estrogens: A review of the data and identification of knowledge gaps

@article{Mattison2014PharmacoAT,
  title={Pharmaco- and toxicokinetics of selected exogenous and endogenous estrogens: A review of the data and identification of knowledge gaps},
  author={Donald R. Mattison and Nataliya A. Karyakina and Michael Goodman and Judy S LaKind},
  journal={Critical Reviews in Toxicology},
  year={2014},
  volume={44},
  pages={696 - 724}
}
Abstract Chemicals with estrogenic activity are derived from many different natural and synthetic processes and products, including endogenous production (e.g., estradiol, conjugated estrogens), drugs (e.g., ethinyl estradiol, conjugated estrogens), plants used as foods (phytoestrogens such as genistein, daidzein, S-equol), and man-made chemicals (xenoestrogens such as bisphenol A). Human exposure to low doses of endogenous estrogens, estrogenic drugs, phytoestrogens, and xenoestrogens has the… Expand
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Bisphenol A: Targeting metabolic tissues
TLDR
Both epidemiological evidence and in vivo experimental data point to an association between BPA exposure and the induction of insulin resistance and/ or disruption of pancreatic beta cell function and/or obesity. Expand
Genistein: Dual Role in Women’s Health
TLDR
The dose-dependent effects of Genistein indicate that consumption of genistein may contribute to beneficial effects in women’s health and disease prevention and treatment, but consumption and exposure levels are nuanced because adverse effects have been observed at lower concentrations in in vitro models. Expand
Occurrence, endocrine-related bioeffects and fate of bisphenol A chemical degradation intermediates and impurities: A review.
TLDR
The objectives of this review were to assess the potential risks to human and environmental health associated with BPA derivatives, characterize the current understanding of BPA's degradation intermediates and co-pollutants, and aid in the identification of compounds of interest that have received insufficient scrutiny. Expand
Interaction of soy isoflavones and their main metabolites with hOATP2B1 transporter
TLDR
It is shown that aglycones of soy isoflavones and the main biologically active metabolite S-equol were able to significantly inhibit hOATP2B1-mediated transport, which may suggest that tested soy is oflavone and their metabolites might affect transport of xenobiotics including drugs across tissue barriers via hOatP2 B1. Expand
Prenatal exposure to bisphenols and parabens and impacts on human physiology.
TLDR
Taking into account the widespread occurrence of various EDs and the potential multiplicity of their effects, doses of EDs currently considered safe may not actually be as safe as they appear, especially during pregnancy. Expand
Effects of flame retardants on arcuate gene expression and energy homeostasis in mice
TLDR
Overall, FR more drastically influenced ARC gene expression in males than in females, suggesting that these FR alter ARC gene Expression in a sex-dependent manner in males. Expand
Neonatal exposure of 17β-estradiol has no effects on mutagenicity of 7,12-dimethylbenz [a] anthracene in reproductive tissues of adult mice
TLDR
Early life exposures of mice to estrogens like E2 do not enhance mutagenicity by subsequent exposure to a chemical like DMBA in later life, suggesting that early life exposed mice to E2 are weak carcinogens via both genetic and epigenetic mechanisms. Expand
Recent advances in simultaneous analysis of bisphenol A and its conjugates in human matrices: Exposure biomarker perspectives.
TLDR
The primary focus was to review the current state of the art in analytical methods available to quantitate BPA conjugates, since they require in vivo metabolism and are not prone to external contamination. Expand
Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes
TLDR
The presented article aimed to review the literature on environmental and clinical exposures to bisphenols and phthalates, highlight experimental work that suggests that these chemicals may exert a negative influence on cardiovascular health, and emphasize areas of concern that relate to vulnerable pediatric groups. Expand
Effects of early exposure to phthalates and bisphenols on cardiometabolic outcomes in pregnancy and childhood.
TLDR
Current knowledge of the effects of fetal and childhood exposure to phthalates and bisphenols on child growth and child cardiometabolic outcomes and the effects on maternal outcomes is summarized. Expand
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