Pharmaceutical regulation of telomerase and its clinical potential

  title={Pharmaceutical regulation of telomerase and its clinical potential},
  author={Alyssa A Sprouse and Catherine E Steding and Brittney-Shea Herbert},
  booktitle={Journal of cellular and molecular medicine},
Telomeres serve the dual function of protecting chromosomes from genomic instability as well as protecting the ends of chromosomes from DNA damage machinery. The enzyme responsible for telomere maintenance is telomerase, an enzyme capable of reverse transcription. Telomerase activity is typically limited to specific cell types. However, telomerase activation in somatic cells serves as a key step toward cell immortalization and cancer. Targeting telomerase serves as a potential cancer treatment… CONTINUE READING