Pharmaceutical evaluation of genistein-loaded pluronic micelles for oral delivery.

  title={Pharmaceutical evaluation of genistein-loaded pluronic micelles for oral delivery.},
  author={Suk Hyung Kwon and Sun Young Kim and Kyoung Wook Ha and Myung Kang and Jin Seo Huh and Tae Jong Im and Yong Min Kim and Young Mi Park and Kyoung Hoon Kang and Sangkil Lee and Jung Yun Chang and Jaehwi Lee and Young Wook Choi},
  journal={Archives of pharmacal research},
  volume={30 9},
The purpose of the present study was to determine whether Pluronic F127 polymeric micelles could improve the oral bioavailability of a poor water-soluble drug, such as genistein. Genistein is a phytoestrogen that has estrogenic activity. F127 triblock copolymer consists of PEO100-PPO65-PEO100. Genistein was incorporated in the Pluronic F127 polymeric micelles by a solid dispersion method. The genistein release of genistein-loaded polymeric micelles was studied in vitro (in pH 1.2 and pH 6.8… CONTINUE READING

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