Pharmaceutical characterization of corticosteroid suppository treatment for ulcerative colitis

@article{Sadahiro1992PharmaceuticalCO,
  title={Pharmaceutical characterization of corticosteroid suppository treatment for ulcerative colitis},
  author={Dr. Sotaro Sadahiro and Zenpei Ito and Takashi Kawasaki-shi Kanagawa Iijima and Makoto Noguchi and Kaoru Hosoi},
  journal={Digestive Diseases and Sciences},
  year={1992},
  volume={37},
  pages={1898-1902}
}
The dose and method of administration of a corticosteroid given for the treatment of patients with ulcerative colitis are determined according to the range of the diseased area and its severity. In this study, we prepared a hydrophilic suppository consisting of water-soluble prednisolone sodium succinate (PSL-SS) and a hydrophilic base, polyethylene glycol (PEG), and a hydrophobic suppository consisting of water-insoluble prednisolone (PSL) and a hydrophobic base, Witepsol (WT). We determined… CONTINUE READING
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