Pharmaceutical applications of cyclodextrins: basic science and product development.

@article{Loftsson2010PharmaceuticalAO,
  title={Pharmaceutical applications of cyclodextrins: basic science and product development.},
  author={Thorsteinn Loftsson and M. E. Brewster},
  journal={The Journal of pharmacy and pharmacology},
  year={2010},
  volume={62 11},
  pages={
          1607-21
        }
}
OBJECTIVES Drug pipelines are becoming increasingly difficult to formulate. This is punctuated by both retrospective and prospective analyses that show that while 40% of currently marketed drugs are poorly soluble based on the definition of the biopharmaceutical classification system (BCS), about 90% of drugs in development can be characterized as poorly soluble. Although a number of techniques have been suggested for increasing oral bioavailability and for enabling parenteral formulations… CONTINUE READING
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