Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres.

@article{Feng2006PharmaceuticalAI,
  title={Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres.},
  author={Li Feng and Xian Rong Qi and Xing Jun Zhou and Yoshie Maitani and Shi Wang and Yang Jiang and Tsuneji Nagai},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2006},
  volume={112 1},
  pages={35-42}
}
The objective of the study was to investigate the feasibility of a single-dose hepatitis B vaccine based on three kinds of poly (D, L)-lactide-co-glicolide acid (PLGA) microspheres. PLGA microspheres loaded with recombinant hepatitis B surface antigen (HBsAg) were formulated using a double emulsion microencapsulation technique. The pharmaceutical characteristics of size, surface morphology, protein loading efficiency, antigen integrity, release of HBsAg-loaded PLGA microspheres and degradation… CONTINUE READING
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