Pharmaceutical and clinical development of a novel progesterone formulation

@article{Cometti2015PharmaceuticalAC,
  title={Pharmaceutical and clinical development of a novel progesterone formulation},
  author={Barbara Cometti},
  journal={Acta Obstetricia et Gynecologica Scandinavica},
  year={2015},
  volume={94},
  pages={28 - 37}
}
  • B. Cometti
  • Published 1 November 2015
  • Medicine, Biology
  • Acta Obstetricia et Gynecologica Scandinavica
Progesterone plays an essential role in reproductive events. Its use for luteal support in patients undergoing infertility treatment is an established practice. The different routes used to administer progesterone impact on its efficacy in luteal support: oral administration has been shown to be ineffective due to an extensive first‐pass metabolism in the liver; vaginal application has a good efficacy but has drawbacks such as vaginal leakage, irritation, discomfort and uncertainty about the… 
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