Pharmaceutical and clinical analysis by tandem mass spectrometry.

  title={Pharmaceutical and clinical analysis by tandem mass spectrometry.},
  author={Richard A. Yost and Robert J. Perchalski and Harry O. Brotherton and J V Johnson and Marge Budd},
  volume={31 10 Pt 2},
Tandem mass spectrometry (MS/MS) is a promising technique for trace determination of compounds in complex mixtures. The application of triple-quadrupole MS/MS to clinical and pharmacological studies has been investigated with major emphasis on rapid screening and determination of drugs and biomolecules in physiological fluids and tissues. These techniques have been applied to a range of problems, including the determination of chlorinated compounds in humans, subpicogram analysis of… Expand
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