Pharmaceutical and clinical analysis by tandem mass spectrometry.

@article{Yost1984PharmaceuticalAC,
  title={Pharmaceutical and clinical analysis by tandem mass spectrometry.},
  author={Richard A. Yost and Robert J. Perchalski and Harry O. Brotherton and J V Johnson and Marge Budd},
  journal={Talanta},
  year={1984},
  volume={31 10 Pt 2},
  pages={
          929-35
        }
}
Tandem mass spectrometry (MS/MS) is a promising technique for trace determination of compounds in complex mixtures. The application of triple-quadrupole MS/MS to clinical and pharmacological studies has been investigated with major emphasis on rapid screening and determination of drugs and biomolecules in physiological fluids and tissues. These techniques have been applied to a range of problems, including the determination of chlorinated compounds in humans, subpicogram analysis of… Expand
Biotransformation and Excretion: Metabolite Identification: Other Mass Spectrometric Methods
TLDR
Tandem mass spectrometry can, in many cases, eliminate the need for chromatography and can provide additional capabilities not obtainable with the relatively slow chromatographic techniques in which sample components must necessarily elute one at a time. Expand
'Metabolic mapping' of drugs: rapid screening techniques for xenobiotic metabolites with m.s./m.s. techniques.
TLDR
The development of tandem mass spectrometry techniques for the rapid structural elucidation and quantification of metabolites is described, which can be used to assess the overall biotransformation routes that are available to a drug or other xenobiotic substance. Expand
Thermospray liquid chromatography tandem mass spectrometry: application to the elucidation of zolpidem metabolism.
TLDR
R reversed phase high-performance liquid chromatography coupled with thermospray LC/MS/MS appears to be the fastest method available today for elucidation of unknown metabolic structures, since it allows identification by direct injection of concentrated urine. Expand
An evaluation of tandem mass spectrometry in drug metabolism studies.
TLDR
There are some problems associated with only using precursor ion and constant neutral loss scanning, including the possibility of not detecting metabolites that undergo unusual collision-induced dissociation fragmentation pathways, and the non-detection of metabolites that have undergone metabolic change at unusual sites of reactivity. Expand
Identification of metabolites of ampicillin using liquid chromatography/thermospray mass spectrometry and fast atom bombardment tandem mass spectrometry.
TLDR
Study showed that only one of the components was eliminated from the body; the other arises from interconversion to the epimer in a urine sample, and it is speculated that the component produced in vivo is the (3S,5R) epimer of ampicillin penilloic acid. Expand
Rapid identification of cimetropium bromide metabolites using constant neutral loss tandem mass spectrometry
A combination of constant neutral loss (CNL) and daughter ion scanning tandem mass spectrometry was used to identify nine metabolites of the antimuscarinic drug cimetropium bromide. CNL massExpand
Bioanalytical applications of tandem mass spectrometry in the in vitro metabolism of the anticholinergic drug cimetropium bromide to detect differences in species metabolism.
1. In vitro metabolism of the anticholinergic drug, cimetropium bromide, was investigated using four different animal hepatic microsomal incubates derived from rat, hamster, guinea pig, and mouseExpand
Identification of AJ-2615 and its S-oxidized metabolites in rat plasma by use of tandem-mass spectrometry.
TLDR
The structural elucidation of the metabolites of a new calcium entry blocker, AJ-2615 (AJ), in rat plasma is described and the presence of the two diastereomeric S-oxides of AJ in the plasma extract was ascertained by high-performance liquid chromatography. Expand
Narrow-bore liquid chromatography-tandem mass spectrometry with simultaneous radioactivity monitoring for partially characterizing the biliary metabolites of an arginine fluoroalkyl ketone analog of D-MePhe-Pro-Arg, a potent thrombin inhibitor.
TLDR
This system was used for rapidly characterizing the biliary metabolites of an arginine fluoroalkyl ketone analog of D-MePhe-Pro-Arg, a potent thrombin inhibitor currently being evaluated as a drug candidate. Expand
On-line continuous-flow dialysis thermospray tandem mass spectrometry for quantitative screening of drugs in plasma: rogletimide.
TLDR
The application of a continuous-flow dialysis system in on-line combination with tandem mass spectrometry via a thermospray interface is described, and the potential of the method is demonstrated by the quantitative analysis of the anti-cancer drug rogletimide in the plasma of patients after treatment. Expand
...
1
2
...