Pharmaceutical Applications of Shellac: Moisture-Protective and Taste-Masking Coatings and Extended-Release Matrix Tablets

@article{Pearnchob2003PharmaceuticalAO,
  title={Pharmaceutical Applications of Shellac: Moisture-Protective and Taste-Masking Coatings and Extended-Release Matrix Tablets},
  author={Nantharat Pearnchob and Juergen Siepmann and Roland Bodmeier},
  journal={Drug Development and Industrial Pharmacy},
  year={2003},
  volume={29},
  pages={925 - 938}
}
Abstract Shellac is a natural polymer, which is used as enteric coating material in pharmaceutical applications. The major objective of the present study was to investigate the potential of shellac for other purposes, namely to provide moisture-protective and taste-masking coatings as well as extended-release matrix tablets. The efficiency of shellac to achieve moisture protection and taste masking was compared with that of hydroxypropyl methylcellulose (HPMC), which is most frequently used for… 
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107 Citations
Background Citations
26
Methods Citations
5

107 Citations

Effect of coating excipients on chemical stability of active coated tablets
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Higher stability of triacetin systems over PEG systems was attributed to lower solubility and mobility of peliglitazar in HPMC compared with the PVA-based coating, while for the same plasticizer/detackifier, higher stability of H PMC over PVA, based on the overall stability for the film-forming polymer-plasticizer/ Detackifier combination.
Protection of moisture-sensitive drugs with aqueous polymer coatings: importance of coating and curing conditions.
Formulation and Development of Aqueous Film Coating for Moisture Protection of Hygroscopic Herniaria glabra L. Tablets
Objectives The present study aims to develop a moisture-protective coating solution and use it to film coat hygroscopic Herniaria glabra L. tablets. Materials and Methods Five coating formulations…
Modification of shellac coating using Jeffamine® for enhanced mechanical properties and stability
An Update of Moisture Barrier Coating for Drug Delivery
TLDR
Different strategies have been designed and developed to effectively decrease water vapor permeability and improve the moisture barrier function of the film and could potentially replace the current solvent and aqueous coatings.
Modulation of drug release kinetics of shellac-based matrix tablets by in-situ polymerization through annealing process.
Investigation of drug release from pellets coated with different shellac types
TLDR
The Thai shellac stands out providing both gastric resistance at low CLs and fast drug release at high pH 6.8, and the intrinsic dissolution rate turned out to be a good indicator for the drug release behavior.
Taste masking of naproxen sodium granules by fluid-bed coating
TLDR
An optimum ratio between naproxen sodium granules and Eudragit® E was found to be 1:1.576, where less naproxin sodium was released than the threshold bitter value and an appropriate taste masking for more than 5 min was guaranteed.
Influence of the inlet air temperature in a fluid bed coating process on drug release from shellac-coated pellets
TLDR
Pellets coated at lower temperatures showed distinct cracks in the coating film resulting in a loss of the barrier function during dissolution testing, and these cracks were nonreversible by additional curing.
Quality Properties of Enteric-Coated Soft Capsule Using PEG as a Plasticizer
We investigated the applicability of polyethylene glycol (PEG) as a plasticizer in enteric-coated soft capsules based on determination of quality characteristics according to molecular weight and…
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